Researchers discover bifunctional lipopeptide antibiotic with a low resistance potential

Antibiotic rifampicin attenuates C9orf72-linked dementia in genetically modified mice

Through bioinformatics prospecting, researchers discovered and synthesized a novel, naturally-inspired, bifunctional lipopeptide antibiotic with low resistance potential. The antibiotic compound, which the authors named cilagicin, demonstrated potent and broad antimicrobial activity against several Gram-positive bacteria in laboratory tests, including hard-to-treat resistant strains like Clostridioides difficile and resistant to vancomycin Enterococcimaking it an attractive candidate for … Read more

New therapeutic approach harnesses the body’s immune system to protect against brain damage

Five different diseases attack language areas in the brain that cause primary progressive aphasia

A therapeutic method to harness the body’s immune system to protect against brain damage is published today by researchers from the Babraham Institute’s Immunology Research Program. The collaboration between Prof. Adrian Liston (Babraham Institute) and Prof. Matthew Holt (VIB and KU Leuven; i3S-University of Porto) has produced a targeted delivery system to increase the number … Read more

Research offers entirely new ways to visualize cell membranes

Researchers develop universal AI algorithm to "clean" noisy single-cell RNA sequencing data

Research from Matthew Lew’s lab at Washington University in St. Louis offers entirely new ways to see the very small. The research -; two papers by PhD students at the McKelvey School of Engineering -; has been published in journals Optical and Nano-letters. They have developed new hardware and algorithms that allow them to visualize … Read more

Risk factors for COVID-19 in patients with hematological malignancies

Study: Hematologic malignancies and COVID-19 infection: a monocenter retrospective study. Image Credit: Chaikom / Shutterstock.com

Cancer patients have historically been at higher risk of developing severe coronavirus disease 2019 (COVID-19) due to underlying malignancies that undermine the immune system and the common use of immunosuppressive treatments in these patients. Many patients and healthcare workers have had to make difficult decisions about delaying or stopping chemotherapy to better treat COVID-19 in … Read more

New initiative aims to increase collaboration and accelerate high-impact cancer immunotherapy

LJI researchers uncover new drug target for severe asthma, lung fibrosis

The accelerated advancement of cancer immunology and immunotherapy, a type of biological therapy that enhances the immune system’s ability to recognize and kill cancer cells, has dramatically improved cancer treatment effectiveness and outcomes. for patients. An initiative brings together researchers studying immunotherapy to increase collaboration and accelerate high-impact immunotherapy research: the Cancer Immunology and Immunotherapy … Read more

Researchers identify the genetic causes of three mitochondrial diseases using new approach

Genetic cause of lupus identified

When something goes wrong in the mitochondria, the tiny organelles that fuel cells, it can cause a bewildering variety of symptoms such as poor growth, fatigue and weakness, seizures, developmental and cognitive impairment. and vision problems. The culprit could be a defect in one of the approximately 1,300 proteins that make up mitochondria, but scientists … Read more

Review addresses the need for innovative adjuvant approaches and delivery strategies for the advancement of new mucosal vaccines

Study: Mucosal vaccines — fortifying the frontiers. Image Credit: PhotobyTawat/Shutterstock

In a recent study published in Journals Nature Immunologyresearchers reviewed available mucosal vaccines discussing current challenges and ways to advance existing approaches. Study: Mucosal vaccines — fortifying borders. Image Credit: PhotobyTawat/Shutterstock Background The burden of disease and mortality associated with infectious diseases caused by mucosal pathogens is alarming worldwide. The current coronavirus disease 2019 (COVID-19) … Read more

Hydration restores airway integrity in people with cystic fibrosis

UH experts in cloning and stem cell science take the first step toward unraveling cystic fibrosis

Cystic fibrosis is a rare genetic disease that can cause very serious symptoms. In particular, patients suffer from chronic bacterial infections that can lead to respiratory failure. It is caused by mutations in the CFTR gene, which regulates the movement of water across the cell membrane. Therefore, the quality of mucus is impaired, it is … Read more

UH experts in cloning and stem cell science take the first step toward unraveling cystic fibrosis

UH experts in cloning and stem cell science take the first step toward unraveling cystic fibrosis

Two nationally recognized experts in cloning and stem cell science from the University of Houston take the first step towards limiting the consequences of chronic inflammation in cystic fibrosis (CF) by identifying the source of this inflammation persistent and enigmatic in CF lungs. Frank McKeon and Wa Xian of the UH Department of Biology and … Read more

Study identifies a gene that plays an important role in embryo development

Study identifies a gene that plays an important role in embryo development

A new study co-led by a Cedars-Sinai researcher has identified a gene that plays an important role in a biological pathway involved in embryonic development. The impact of the gene at the cellular level could explain why some babies are born with physical abnormalities and why some adults develop diseases like cancer. The findings are … Read more